Inombolo yeCas: 54-31-9 Ifomula yeMolekyuli:C12H11ClN2O5S
| Indawo yokunyibilika | 261-263°C |
| Ukuxinana | 1.16 (uqikelelo olurhabaxa) |
| ixesha lokugcina | Umoya ongaphakathi, Ubushushu beGumbi 2-8°C |
| ukunyibilika | I-DMSO: > 5 mg/mL ku-60 °C |
| umsebenzi wamehlo | N / A |
| Imbonakalo | I-Off-White Solid |
| Ubunyulu | ≥98% |
I-Telmisartan yasungulwa e-US kunyango lwe-hypertension.Inokulungiswa ngamanyathelo asibhozo aqala nge-methyl 4-amino-3-methyl benzoate;I-cyclization yokuqala neyesibini kwi-benzimidazole ring yenzeke kumanyathelo 4 kunye ne-6 ngokulandelelanayo.I-Telmisartan ivimba isenzo se-angiotensin II (Ang II), eyona molekyuli yesiphumo se-renin-angiotensin-aldosterone system (RAAS).Yesithandathu kolu didi lwe 《sartans》 ukuthengiswa emva kwekhompawundi ekhokelayo iLosartan.Isiphumo saso esihlala ixesha elide (i-24h isiqingatha-ubomi) ingaba ngumahluko ophambili kunye nabanye abachasayo be-angiotensin II.Ngokungafaniyo nezinye ii-agent ezininzi kolu didi, umsebenzi walo awuxhomekekanga kwinguqu kwi-metabolite esebenzayo, i-1-O-acylglucuronide yeyona metabolite ephambili efumaneka ebantwini.I-Telmisartan ngumchasi onamandla okhuphisanayo we-AT1 receptors elamla uninzi lweziphumo ezibalulekileyo ze-angiotensin II ngelixa ingenabudlelwane kwi-AT2 subtypes okanye ezinye ii-receptors ezibandakanyekayo kulawulo lwentliziyo.Kwizifundo ezininzi zeklinikhi, i-Telmisartan, kwidosi enye yonke imihla, yavelisa iziphumo ezisebenzayo nezizinzileyo zokwehliswa koxinzelelo lwegazi kunye nezehlo ezisezantsi zeziphumo ebezingalindelekanga (ingakumbi ukhohlokhohlo olunxulumene nonyango olunxulumene ne-ACE inhibitors kwizigulana esele zikhulile).
I-Telmisartan sisichasi se-angiotensin II receptor.
