Inombolo yeCas: 146-56-5 Ifomula yeMolekyuli: C20H21ClN2O4
| Indawo yokunyibilika | 176-178°C |
| Ukuxinana | 1.02 g/cm³ |
| ixesha lokugcina | ikrazukile kubushushu begumbi, ngaphandle kwelanga nakwindawo efumileyo |
| ukunyibilika | 50 mg/ml (kwi-ethanol);Ayinyibiliki emanzini |
| umsebenzi wamehlo | +111.6 degrees (C=1, methanol) |
| Imbonakalo | emhlophe okanye phantse emhlophe crystalline powder |
| Ubunyulu | ≥97% |
"i-dihydropyridine calcium antagonist" (i-calcium antagonist, okanye i-block blocker ecothayo) ethintela ukuhamba kwe "calcium ion" kwiiseli ze-vascular smooth muscle kunye ne-myocytes yentliziyo.Idatha yovavanyo icebisa ukuba inxulunyaniswa "neendawo ezibophelelayo" ze "dihydropyridines" kunye ne "non-dihydropyridines".Zombini i-cardiac kunye ne-vascular smooth muscle 'iinkqubo zecontractile' zixhomekeke ekungeneni kwe-'extracellular calcium ion' kwezi seli ngokusebenzisa imijelo ye-ion ethile.ngokukhethayo inqanda ukuhamba kwee-ion ze-calcium kuzo zonke iiseli zeseli, indlela echaphazela iiseli ze-vascular smooth muscle ngaphezu kweeseli zentliziyo.Isiphumo esibi se-inotropic (Inotrope), okanye ukunciphisa i-contractility ye-myocardial, inokubonwa kwi-vitro.Nangona kunjalo, iziphumo ezinjalo azizange zibonwe kwizilwanyana ezilawulwa kwi-dose emiselweyo yonyango.I-serum calcium concentrations ayichatshazelwa yi.Kuluhlu lwe-pH ye-physiological, i-ionised compound (pKa = 8.6) intsebenziswano kunye ne-calcium channel receptors ibonakala ngesantya esiqhubekayo se-receptor esibophezelayo indawo yokudibanisa kunye nokwahlukana, kwaye le ndlela yesantya eqhubekayo iphumela kwisiphumo sokuqala esiqhubekayo.
i-peripheral arterial vasodilator esebenza ngokuthe ngqo kwi-vascular smooth muscle, okukhokelela ekunciphiseni ukuxhatshazwa kwe-vascular peripheral kunye nokunciphisa uxinzelelo lwegazi.Indlela echanekileyo yokuphelisa i-angina ayiqondwa ngokupheleleyo, kodwa kucingelwa ukuba iquka oku kulandelayo: I-angina yokuzivocavoca: Kwizigulane ezine-angina esebenzayo, i-NORVASC inciphisa ukuxhathisa kwe-peripheral (emva kokulayishwa) ngexesha lomsebenzi wentliziyo kulo naliphi na izinga lokuzilolonga kunye nokunciphisa izinga. imveliso yoxinzelelo, ngaloo ndlela inciphisa imfuno yeoksijini ye-myocardial.
Ekuqaleni i-5mg kanye imihla ngemihla, inyuka ukuya kwi-10mg ephezulu kanye ngosuku.
