Inombolo yeCas: 147403-03-0 Ifomula yeMolekyuli: C24H29N5O3
| Indawo yokunyibilika | 230°C |
| Ukuxinana | 1.41g/cm³ |
| ixesha lokugcina | 2-8℃ |
| ukunyibilika | Iphantse inganyibiliki emanzini, kwaye ukunyibilika kwi-ethanol yi-5.5 mg/m |
| umsebenzi wamehlo | +76.5 degrees (C=1, ethanol) |
| Imbonakalo | emhlophe okanye emhlophe eqinileyo, engenavumba |
i-non peptide, ngomlomo i-angiotensin II (AT) receptor antagonist esebenzayo.Inokukhethwa okuphezulu ngokubhekiselele kuhlobo lwe-I receptor (AT1) kwaye inokuchaswa ngokukhuphisana ngaphandle kwemiphumo evuselelayo.Iyakwazi nokuthintela ukukhutshwa kwe-aldosterol ye-AT1 ye-receptor mediated ukusuka kwiiseli ze-adrenal glomerular, kodwa ayinayo impembelelo yokuthintela ekukhutshweni kwe-potassium, ebonisa umphumo wayo okhethiweyo kwi-AT1 receptors.Iimvavanyo ze-vivo kwiindidi ezahlukeneyo zezilwanyana zezilwanyana zibonise ukuba zinefuthe elihle le-antihypertensive kwaye ayinayo impembelelo ebalulekileyo kumsebenzi we-contractile we-cardiac kunye nesantya senhliziyo.Akukho mpembelelo ye-antihypertensive kwizilwanyana ezinoxinzelelo lwegazi oluqhelekileyo
Amachiza okulwa noxinzelelo lwegazi.ngumchasi we-angiotensin II (Ang II) othintela ngokukhethekileyo ukubophelela kwe-Ang II kwi-AT1 receptors (isiphumo sayo esichasayo kwi-AT1 receptors malunga namaxesha angama-20000 amakhulu kune-AT2), ngaloo ndlela inqanda ukuchithwa kwe-vascular kunye nokukhululwa kwe-aldosterone, okukhokelela ekubeni iziphumo ze-hypotensive
I-dose yokuqala ekhuthazwayo yeepilisi yi-80mg (iipilisi ezi-2), ezithathwe ngomlomo kanye ngosuku.Ngokuqhelekileyo, ukuba ayisebenzi kwiiveki ze-4, umthamo unokunyuswa ukuya kwi-160mg (iipilisi ezi-4) kanye ngosuku.Ngokutsho kwedatha yesicelo seklinikhi yangaphandle, umthamo ophezulu unokufikelela kwi-320mg (iipilisi ezi-8) kanye ngosuku
1. Izigulana ezinoxinzelelo lwegazi olunzima kunye nesifo seswekile, uxinzelelo lwegazi olunzima kunye ne-nephropathy okanye i-nephropathy elula yeswekile,
I-2.izigulane ezine-hypertension enzima ngokuhluleka kwentliziyo okanye i-myocardial infarction
