Inombolo yeCas: 21187-98-4 iFomula yeMolekyuli

Inkcazelo emfutshane:

Inombolo yeCas: 21187-98-4

Igama leMchiza:

Ifomula yeemolekyuli:C15H21N3O3S

Izithethantonye:BP;)-4-methyl-;1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl) urea;1-(hexahydrocyclopenta(c)pyrrol-2(1h )-yl)-3-(p-tolylsulfonyl)-ure;1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)urea;benzenesulfonamide,n-(((hexahydrocyclopenta() c)pyrrol-2(1h)-yl)amino)carbonyl;n-(4-methylbenzenesulfonyl)-n'-(3-azabicyclo(3.3.0)oct-3-yl)urea;Tetrabenzyl Voglibose HCl

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Inkcazo yeeMveliso

Indawo yokunyibilika	163-169 °C
Ukuxinana	1.2205 (uqikelelo olurhabaxa)
ixesha lokugcina	Umoya ongaphakathi, Ubushushu beGumbi 2-8°C
ukunyibilika	I-methylene chloride: i-soluble
umsebenzi wamehlo	N / A
Imbonakalo	I-Off-White Solid
Ubunyulu	≥98%

Inkcazo

i-agent yomlomo ye-antihyperglycemic esetyenziselwa unyango lwe-diabetes mellitus type II.Kudidi lwe-sulfonylurea ye-insulin secretagogues, evuselela iiseli ze-β ze-pancreas ukuba zikhuphe i-insulin.ibophelela kwi-β cell sulfonyl urea receptor (SUR1), ikhusela ngakumbi i-ATP iziteshi ze-potassium ezibuthathaka.Ke ngoko, i-potassium efflux yehla kakhulu, ibangela ukuchithwa kweeseli ze-β.Emva koko amajelo e-calcium axhomekeke kumbane kwiseli ye-β avuliwe, nto leyo ekhokelela ekubeni kusebenze i-callodulin, nto leyo ekhokelela kwi-exocytosis ye-insulin equlethe i-secretory granules.Uphononongo lwakutsha nje luye lwabonisa ukuba lunokuphucula imeko ye-anti-oxidant kunye ne-nitric oxide-mediated vasodilation kwi-Type 2 yeswekile kwaye ikhusele iiseli ze-pancreatic beta emonakalweni yi-hydrogen peroxide.

ukusetyenziswa kunye nethamo

i-agent yomlomo ye-hypoglycemic esetyenziselwa ukuphatha isifo sikashukela esingaxhomekekanga kwi-insulin.Unyango lwesifo sikashukela esihambelana nokukhuluphala okanye isifo se-vascular, kubantu abadala abanesifo sikashukela sohlobo lwe-2. Isifo sikashukela yimeko yempilo engapheliyo (ehlala ixesha elide) echaphazela indlela umzimba wakho ujika ngayo. ukutya kube amandla.kunciphisa amanqanaba eswekile yegazi ngokuvuselela ukukhutshwa kwe-insulin kwiiseli ze-β zeziqithi zeLangerhans.