Inombolo yeCas: 330784-47-9 Ifomula yeMolekyuli: C23H26ClN7O3

Inkcazelo emfutshane:

Inombolo yeCas: 330784-47-9

Igama leMchiza:

Ifomula yeemolekyuli:C23H26ClN7O3

Izithethantonye:(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

4-[(3-Chloro-4-methoxybenzyl) amino] -2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Inkcazo yeeMveliso

Indawo yokunyibilika	150-152°C
Ukuxinana	1.372
ixesha lokugcina	Itywinwe kwindawo eyomileyo, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C
ukunyibilika	I-DMSO (Kancinci), iMethanol (Kancinci, ishushu)
umsebenzi wamehlo	N / A
Imbonakalo	Mhlophe ukuya kuMhlophe
Ubunyulu	≥98%

i-pharmacodynamics

(I-Zepeed) yavunywa nguMphathiswa wezeMpilo waseKorea kunyango lwe-erectile dysfunction (ED) ngo-Agasti 2011.i-inhibitor ekhethiweyo kakhulu ye-5 phosphodiesterase (PDE5).kuxelwe ukuba yeyona PDE5 inhibitor ekhethiweyo kwimarike.Ukuqala kwe-Tmax kunye nesiqingatha sobomi kuyahluka phakathi kwee-PDE5 inhibitors ezithengiswayo.I-Sildenafil ine-T_maxkwi-1 h kunye nesiqingatha-ubomi be-3-5 h.IVardenafil iyafana neT_maxof 0.6 h kunye nesiqingatha-ubomi 4–6 h.I-Tadalafil inobomi obude kakhulu phakathi kweziyobisi ezithengiswayo kunye nesiqingatha sobomi be-17 h.unesiqalo esikhawulezayo sesenzo esifikelela ku-T_maxkwi-0.6 h kunye nesiqingatha sobomi be-1.2 h.I-synthesis ye (TA-1790) ichazwe kuncwadi lwelungelo elilodwa lomenzi wechiza.Eyona ndlela iphambili yokuphelisa yinyongo kunye nelilindle.Kwaye kwafunyaniswa ukuba iphinde ifakwe kwakhona nge-enterohepatic recirculation.