Inombolo ye-Cetilistat Cas: 282526-98-1 Ifomula yeMolekyuli:C25H39NO3

Inkcazelo emfutshane:

Inombolo yeCas: 282526-98-1

Igama leKhemikhali: Cetilistat

Ifomula yemolekyuli:C25H39NO3

Izithethantonye:cetilistat Cetilistat(Alt-962) Cetilstat 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-enye

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

ukucaciswa kweemveliso

Indawo yokunyibilika	72.0 ukuya 76.0 °C
Ukuxinana	1.02
ixesha lokugcina	Itywinwe kwindawo eyomileyo,2-8°C
ukunyibilika	I-Chloroform (Kancinci), i-Ethyl Acetate (Kancinci)
umsebenzi wamehlo	N / A
Imbonakalo	I-Cryst emhlophe
Ubunyulu	≥98%

i-pharmacodynamics

I-Cetilistat (eyaziwa ngokuba yi-ATL-962) yamkelwa ngoSeptemba 2013 nguMphathiswa wezeMpilo waseJapan, uMsebenzi kunye neNtlalontle kunyango lokukhuluphala, kuphela kwizigulane ezine-2 yeswekile mellitus (T2DM) kunye ne-dyslipidemia, kunye nobunzima bomzimba. isalathisi (BMI)25 kg/m²ngaphandle konyango lokutya kunye/okanye unyango lokuzilolonga.Njenge-orlistat, i-cetilistat isebenza ngokunqanda i-pancreatic lipases emathunjini ukuthintela ukufunxa kwamafutha kwaye ngaloo ndlela kuncitshiswe ukuthathwa kwekhalori ekudleni.Inkqubo yekhemistri yamayeza ayichazwanga kuncwadi lwenzululwazi, kodwa i-patent echaza i-cetilistat ikwachaza ukuhlanganiswa kwee-analogs kunye ne-aryl substituents kunye nemisila ye-lipophilic.Ukwenziwa kwe-cetilistat kubandakanya ukunyuswa kwe-hexadecylcarbonochloridate kunye ne-2-amino-5-methylbenzoic acid;ezinye analogs zaye zaxutywa ngokwahluka carbonochloridate kunye 2-aminobenzoic amacandelo acid.I-Cetilistat yi-inhibitor enamandla yomntu kunye ne-rat pancreatic lipase kunye ne-IC_50sye-15 kunye ne-136 nM, ngokulandelelana, kunye nokuvinjelwa okuncinci kwe-trypsin okanye i-chymotrypsin.