Inombolo yeCas: 144701-48-4 Ifomula yeMolekyuli:C33H30N4O2

Inkcazelo emfutshane:

Inombolo yeCas: 144701-48-4
Igama leMchiza:
Ifomula yeemolekyuli:C33H30N4O2

Izithethantonye:MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277;PRITOR;BIBR 277;misartan;BIBR 277SE

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Iinkcukacha zeMveliso

Iithegi zeMveliso

Inkcazo yeeMveliso

Indawo yokunyibilika	261-263°C
Ukuxinana	1.16 (uqikelelo olurhabaxa)
ixesha lokugcina	Umoya ongaphakathi, Ubushushu beGumbi 2-8°C
ukunyibilika	I-DMSO: > 5 mg/mL ku-60 °C
umsebenzi wamehlo	N / A
Imbonakalo	I-Off-White Solid
Ubunyulu	≥98%

Inkcazo

yasungulwa e-US kunyango lwe-hypertension.Inokulungiswa ngamanyathelo asibhozo aqala nge-methyl 4-amino-3-methyl benzoate;I-cyclization yokuqala neyesibini kwi-benzimidazole ring yenzeke kumanyathelo 4 kunye ne-6 ngokulandelelanayo.ivimbela isenzo se-angiotensin II (i-Ang II), i-molekyuli ye-primary effector ye-renin-angiotensin-aldosterone system (RAAS).Yesithandathu kolu didi lwe 《sartans》 ukuthengiswa emva kwekhompawundi ekhokelayo iLosartan.Isiphumo saso esihlala ixesha elide (i-24h isiqingatha-ubomi) ingaba ngumahluko ophambili kunye nabanye abachasayo be-angiotensin II.Ngokungafaniyo nezinye ii-arhente ezikolu didi, umsebenzi walo awuxhomekekanga kuguquko lwe-metabolite esebenzayo, i-1-O-acylglucuronide yeyona metabolite ephambili efumaneka ebantwini. I-angiotensin II ngelixa ingenabudlelwane kwi-AT2 subtypes okanye ezinye ii-receptors ezibandakanyekayo kulawulo lwentliziyo.Kwizifundo ezininzi zeklinikhi, kwidosi yemihla ngemihla, zivelise iziphumo ezisebenzayo nezizinzileyo zokwehliswa koxinzelelo lwegazi kunye nezehlo ezisezantsi zeziphumo ebezingalindelekanga (ingakumbi ukhohlokhohlo olunxulumene nonyango olunxulunyaniswa ne-ACE inhibitors kwizigulana ezisele zikhulile).