Inombolo yeRifampicin Cas: 13292-46-1 Ifomula yeMolekyuli: C43H58N4O12

Inkcazelo emfutshane:

Inombolo yeCas:13292-46-1

Igama leMchiza:Rifampicin

Ifomula yemolekyuli:
I-C43H58N4O12

Izithethantonye:9,17,19,21-hexahydroxy-23-methoxy-2,4,12,1///;2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) Furan-1,11(2-h) -dione,5,6;3-(((4-methyl-1-piperazinyl)imino)methyl)-rifamyci;3-((4-methyl-1-piperazinyl)iminomethyl) ) rifamycinsv;8-(((4-methyl-1-piperazinyl)imino)methyl)rifamycinsv;8-(4-Methylpiperazinyliminomethyl)rifamycinSV;8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins; I-RIFAMPIN "LEPETIT"

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Inkcazo yeeMveliso

Indawo yokunyibilika	183 °
Ukuxinana	1.1782(uqikelelo olurhabaxa)
ixesha lokugcina	2-8°C
ukunyibilika	i-chloroform: i-soluble50mg/mL, icacile
umsebenzi wamehlo	N / A
Imbonakalo	ibomvu ebomvu ukuya kubomvu obumnyama kakhulu
Ubunyulu	≥99%

Inkcazo

I-Rifampicin yi-semisynthetic derivative ye-rifamicin B, i-macrolactam antibiotic kunye nenye yamayeza okubulala iintsholongwane angaphezu kwesihlanu kumxube we-rifamicins A, B, C, D, no-E, obizwa ngokuba yi-rifamicin complex, eveliswa yi-actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).Yaziswa kunyango ngo-1968. I-Synthesis ye-rifampicin iqala ngesisombululo esimanzi se-rifamicin, phantsi kweemeko zokusabela i-oxidized kwi-derivative entsha ye-rifamicin S (32.7.4), kunye nokusekwa okuphakathi kwe-rifamicin O (32.7. 3).Ukunciphisa i-quinone yale mveliso nge-hydrogen usebenzisa i-palladium kwi-carbon catalyst inika i-rifamicin SV (32.7.5).Imveliso ephumelayo ifumana i-aminomethylation ngomxube we-formaldehyde kunye ne-pyrrolidine, ukunika i-3-pyrrolidinomethylrifamicin SV (32.7.6).I-Oxidizing imveliso ephumayo kunye ne-lead tetracetate kwi-enamine kunye ne-hydrolysis elandelayo kunye nesisombululo esimanzi se-ascorbic acid inika i-3-formylrifamicin SV (32.7.7).Ukuphendula oku nge-1-amino-4-methylpiperazine kunika i-rifampicin efunekayo (32.7.8).

ukusetyenziswa kunye nethamo

I-Rifampin isetyenziswa njengeyeza lokubulala iintsholongwane.Yinto ephuma kwi-semisynthetic ye-rifamycin B, isithinteli-ntsholongwane se-macrocyclic esiveliswe ngumbumba iStreptomyces mediterranei.I-Rifampin isetyenziselwa unyango lwesifo sephepha, i-brucellosis, i-Staphlococcus aureus, kunye nezinye izifo ezithathelwanayo.