Inombolo yeCas: 224785-91-5 Ifomula yeMolekyuli:C23H33ClN6O4S

Inkcazelo emfutshane:

Inombolo yeCas: 224785-91-5

Igama leMchiza:

Izithethantonye: HCL;Vardenafi;Nuviva;fafinafei;Valdenafil;Levitra, Valdenafil;USP/EP/BP;Levitra,Valdenafil.HCl;224785-91-5;

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Inkcazo yeeMveliso

Indawo yokunyibilika	214-216°C
Ukuxinana	N / A
ixesha lokugcina	Umoya ongaphakathi, 2-8°C
ukunyibilika	N / A
umsebenzi wamehlo	N / A
Imbonakalo	Mhlophe ukuya kwi-Off-White Cyrstalline
Ubunyulu	≥98%

i-pharmacodynamics

yayiyi-arhente yesibini ukuthengiswa kwaye yayine-advanteji yokuba ixesha layo lokuqala alizange lincitshiswe ngokusela iyeza kwisisu esipheleleyo.Ngamaxesha e-30 anamandla njenge-inhibitor ye-PDE5 (ithetha i-IC50, i-3.9 nM) kune-sildenafil kunye namaxesha e-10 anamandla ngaphezu kwe-tadalafil, ngokukhetha okukhulu (> amaxesha angama-1,000) kwi-PDE5 yabantu kune-PDE2 yabantu, i-PDE3, kunye ne-PDE4 kunye ukukhetha okuphakathi (> amaxesha angama-80) kwi-PDE1.I-PDE inhibitory selectivity kunye ne-in vitro kunye ne-vivo potency ye-PDE5 inhibitor entsha.ivimbele ngokukodwa i-hydrolysis ye-cGMP nge-PDE5, kunye ne-IC50 ye-0.7 nM (sildenafil 6.6 nM).I-IC50 ye-PDE1 yayiyi-180 nM, ye-PDE6 11 nM, kunye ne-PDE2, i-PDE3 kunye ne-PDE4 ngaphezu kwe-1,000 nM.